Absolute Configuration


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Absolute Configuration

A term of art referring to the arrangement of atoms around a molecule’s chiral centre.
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The observed sign of the E band at around 322 nm in the induced CD spectrum was correlated to the absolute configuration of the C-15 (or C-14) secondary alcohol moiety.
To determine the absolute configuration of C-9 in 1, (S)- and (R)-MTPA esters (1a and 1b) were prepared.
In 1973 when I began the synthesis of (S)-2, almost nothing was known about the absolute configuration of chiral and non-racemic pheromones, and it was not even clear whether enantiomeric composition would play a role at all in pheromonal communications.
Kita, "A novel determination method of the absolute configuration of 1-aryl-1-alkylalcohols and amines by an intramolecular CH/re shielding effect in 'H NMR," Tetrahedron Letters, vol.
In order to identify compound 1 unequivocally, its absolute configuration was investigated by circular dichroism.
In addition to bioassays, the absolute configuration of naturally occurring lamoxirene 1 in Undaria pinnatifida is confirmed by chiral gas chromatography.
For example, there is a table on isomerism and fluxionality, subdivided into eight categories such as recemization, absolute configuration, and linkage isomerism.
The modified Mosher method was tried to apply assigning the C-6 absolute configuration of 1.
Twenty-five chapters start off with a historical overview and then address such topics as electronic CD of benzene and other aromatic chromophores for determination of absolute configuration, electronic circular dichroism of supramolecular systems, protein-nucleic acid interactions, carbohydrates and glycoconjugates, and drug discovery.
Ten chapters discuss stereochemistry of molecules in inclusion crystals, torsional motion of Stilbene-type molecules in crystals, supramolecular networks of porphyrins, homo- and heterochirality in crystals, supramolecular synthesis of one-dimensional chains and two-dimensional layer in hydrogen bond networks of ureas and two-pyrimidinones, chiral auxiliaries powerful for both enantiomer resolution and determination of absolute configuration by x-ray crystallography, stereoselective thermal solid-state reactions, and other topics.