Absolute Configuration


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Absolute Configuration

A term of art referring to the arrangement of atoms around a molecule’s chiral centre.
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In 1973 when I began the synthesis of (S)-2, almost nothing was known about the absolute configuration of chiral and non-racemic pheromones, and it was not even clear whether enantiomeric composition would play a role at all in pheromonal communications.
The absolute configuration of the natural pheromone can thus be clarified and established.
In order to identify compound 1 unequivocally, its absolute configuration was investigated by circular dichroism.
Circular dichroism, a powerfull tool for the assessment of absolute configuration of flavonoids.
In addition to bioassays, the absolute configuration of naturally occurring lamoxirene 1 in Undaria pinnatifida is confirmed by chiral gas chromatography.
Absolute configuration and enantiomer composition of hormosirene.
SMART again can be of assistance, as it is capable of determining absolute configurations.
6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS
Though the X8 PROSPECTOR is primarily targeted towards crystal screening it features flexible, user-friendly software which allows it also to be used for other applications, such as absolute configuration of light-atom molecules and protein structure determination.
Their focus is on the principles that govern relative and absolute configurations in transition state assemblies.
The next five chapters discuss separations, offering treatments of resolution of chiral drugs and drug intermediates by crystallization, isolation and production of optically pure drugs by enantioselective (able to select one of a chiral pair) chromatography, stereoselective chromatographic methods for drug analysis, capillary electrophoresis coupled to mass spectrometry for chiral drugs analysis, and chiral molecular tools for preparation of enantiopure alcohols and simultaneous determination of their absolute configurations by x-ray crystallography or anisotrophy methods.
The book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers.