Absolute Configuration


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Absolute Configuration

A term of art referring to the arrangement of atoms around a molecule’s chiral centre.
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Circular dichroism, a powerfull tool for the assessment of absolute configuration of flavonoids.
6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS
Their focus is on the principles that govern relative and absolute configurations in transition state assemblies.
The next five chapters discuss separations, offering treatments of resolution of chiral drugs and drug intermediates by crystallization, isolation and production of optically pure drugs by enantioselective (able to select one of a chiral pair) chromatography, stereoselective chromatographic methods for drug analysis, capillary electrophoresis coupled to mass spectrometry for chiral drugs analysis, and chiral molecular tools for preparation of enantiopure alcohols and simultaneous determination of their absolute configurations by x-ray crystallography or anisotrophy methods.
The book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers.