* In Abnormal involuntary movement scale
, patients of both groups had severity of involuntary movements in mild category; however, score was high in Group 1 than Group 2 and score of facial and oral movements in AIMS was high in Group 1 than Group 2.
The primary endpoint will be a comparison of placebo versus active scores on the Abnormal Involuntary Movement Scale
At the same time, they assessed adverse events using the Simpson-Angus Scale, Barnes Akathisia Rating Scale, and the Abnormal Involuntary Movement Scale
. They also measured body weight, serum lipids, and fasting glucose levels.
* Abnormal Involuntary Movement Scale
You routinely administer the Abnormal Involuntary Movement Scale
and discover that one of your patients has developed tardive dyskinesia.
* severity of common side effects is measured by the Simpson-Angus Scale (SAS) for parkinsonism, the Barnes Akathisia Rating Scale (BARS), the Abnormal Involuntary Movement Scale
(AIMS) for tardive dyskinesia, the Glasgow Antipsychotic Side-effect Scale (GASS), etc.
Mean scores on the Abnormal Involuntary Movement Scale
(AIMS) decreased from 12.0 at baseline to 6.4 at the end of the study Patients had abnormal involuntary movements of at least moderate severity, defined as an AIMS score equal to or greater than 3, in at least one body region, persisting for at least 3 months.
Tardive dyskinesia is a difficult condition to treat; it is best, therefore, to prevent its onset by using the minimally effective antipsychotic dose, by preferential use of an SGA rather than a FGA, and by regular screening for tardive dyskinesia using a standardized rating scale such as the Abnormal Involuntary Movement Scale
. Symptoms associated with tardive dyskinesia are more likely to resolve if caught early.
Abnormal Involuntary Movement Scale
: at least moderate in [greater than or equal to] 1 area, or at least mild in [greater than or equal to] 2 areas
Brief assessment scales--such as the Montreal Cognitive Assessment Test, (17) the Abnormal Involuntary Movement Scale
, (18) and the Instrumental Activities of Daily Living Scale (19)--can help you quantify baseline functioning, monitor symptom response, and detect adverse effects.