By inhibiting these gingipains, COR388 aims to protect neurons from bacterial toxicity, lower neuroinflammation and reduce abeta42
production, thereby preventing further cognitive decline and dysfunction.
levels, measured by the saliva test, can lead to dementia.
The study, published in the Journal of Alzheimer's Disease, was based on measuring the concentration of a form of the amyloid beta protein known as Abeta42
that is secreted in saliva.
Mach et al., "Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42
in humans," Annals of Neurology, vol.
Wong, "Impaired neuronal insulin signaling precedes Abeta42
accumulation in female AbetaPPsw/PS1DeltaE9 mice," Journal of Alzheimer's Disease, vol.
Subacute meningoencephalitis in a subset of patients with AD after Abeta42
Tau and Abeta42
in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
(2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42
A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42
DNA vaccine for Alzheimer disease.
In AD-like Tg2576 mice, diet-induced insulin resistance promotes Abeta40 and Abeta42
peptide generation in the brain that corresponds with increased gamma-secretase activities.
(71), (72) "Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Abeta42
and alphasynuclein starting in childhood.
Low cerebrospinal fluid levels of amyloid beta 42 (Abeta42
) and high levels of tau are now seen as important diagnostic hallmarks for Alzheimer's.