Abeta42

One of the 2 cleavage products of amyloid precursor protein, overproduction of which is linked to neurotoxicity in patients with Alzhemier’s disease.

References in periodicals archive ?

By inhibiting these gingipains, COR388 aims to protect neurons from bacterial toxicity, lower neuroinflammation and reduce abeta42 production, thereby preventing further cognitive decline and dysfunction.

Cortexyme Touts Phase 1 Data Demonstrating COR388 is Safe and Well Tolerated in Healthy Older Volunteers and Alzheimer's Patients

Elevated Abeta42 levels, measured by the saliva test, can lead to dementia.

Alzheimer's risk 'seen in saliva test'

The study, published in the Journal of Alzheimer's Disease, was based on measuring the concentration of a form of the amyloid beta protein known as Abeta42 that is secreted in saliva.

Painkiller could put an end to dementia

Mach et al., "Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans," Annals of Neurology, vol.

Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry

Wong, "Impaired neuronal insulin signaling precedes Abeta42 accumulation in female AbetaPPsw/PS1DeltaE9 mice," Journal of Alzheimer's Disease, vol.

Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization.

Inmunoterapia beta-amiloide: ?la esperanza para la enfermedad de alzheimer?

Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.

Importance and impact of preanalytical variables on Alzheimer Disease biomarker concentrations in cerebrospinal fluid

(2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

Novel plasma biomarker surrogating cerebral amyloid deposition

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.

Alzheimer's disease: is a vaccine possible?

In AD-like Tg2576 mice, diet-induced insulin resistance promotes Abeta40 and Abeta42 peptide generation in the brain that corresponds with increased gamma-secretase activities.

Glycogen synthase kinase-3 regulates production of amyloid-[beta] peptides and tau phosphorylation in diabetic rat brain

(71), (72) "Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Abeta42 and alphasynuclein starting in childhood.

Overdosed: fluoride, Copper, and Alzheimer's disease

Low cerebrospinal fluid levels of amyloid beta 42 (Abeta42) and high levels of tau are now seen as important diagnostic hallmarks for Alzheimer's.

AD biomarkers fall short in frontotemporal dementia

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