Abeta42

Abeta42

One of the 2 cleavage products of amyloid precursor protein, overproduction of which is linked to neurotoxicity in patients with Alzhemier’s disease.
References in periodicals archive ?
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization.
Inmunoterapia beta-amiloide: ?la esperanza para la enfermedad de alzheimer?
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
Importance and impact of preanalytical variables on Alzheimer Disease biomarker concentrations in cerebrospinal fluid
2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Novel plasma biomarker surrogating cerebral amyloid deposition
71), (72) "Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Abeta42 and alphasynuclein starting in childhood.
Overdosed: fluoride, Copper, and Alzheimer's disease
All subjects had cerebrospinal fluid drawn for Abeta42, tau, and P-tau levels.
AD biomarkers fall short in frontotemporal dementia
Araclon is currently developing blood tests to measure the amount of the Abeta40 and Abeta42 peptides in the blood.
Amount of Abeta peptides in blood may become biomarker for Alzheimer's disease
Abeta42 has long been thought to be the toxic form of beta amyloid, but until now, no one has understood how the simple addition of two amino acids made it so much more toxic.
New findings about the role beta-amyloid plaques play in Alzheimer's
Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model forAlzheimer's disease.
La intoxicacion con cobre disminuye la sobrevida e induce alteraciones neurologicas en Drosophila melanogaster
The findings suggest that biomarker evidence of Alzheimer's disease begins about 25 years before symptoms are evident: Further, enzymes that produce Abeta42, the protein form most likely to aggregate into brain plaques, might be an effective target for therapy.
Studies bolster Azheimer's amyloid hypothesis
200l, Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta42 Fibrils.
Studies on the Mechanism of Antagonistic Effect of Human Immunoglobulin on the Toxicity of Amyloid ss-Proteins-Treated Murine Nerve Cells
Different enzymes split the APP molecule into the benign Abeta-40, which is secreted into the CSF, and the toxic Abeta42, which forms brain plaques.
Sleep problems may increase dementia risk
Two major forms of Abeta, Abeta40 and Abeta42, have been associated with genetic mutations causing early-onset AD, and have thus received considerable research attention.
RIKEN: Peptide Reveals Clues to Causes of Alzheimer's Disease
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