Abeta42

Abeta42

One of the 2 cleavage products of amyloid precursor protein, overproduction of which is linked to neurotoxicity in patients with Alzhemier’s disease.
References in periodicals archive ?
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization.
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
71), (72) "Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Abeta42 and alphasynuclein starting in childhood.
All subjects had cerebrospinal fluid drawn for Abeta42, tau, and P-tau levels.
Araclon is currently developing blood tests to measure the amount of the Abeta40 and Abeta42 peptides in the blood.
Abeta42 has long been thought to be the toxic form of beta amyloid, but until now, no one has understood how the simple addition of two amino acids made it so much more toxic.
Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model forAlzheimer's disease.
The findings suggest that biomarker evidence of Alzheimer's disease begins about 25 years before symptoms are evident: Further, enzymes that produce Abeta42, the protein form most likely to aggregate into brain plaques, might be an effective target for therapy.
200l, Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta42 Fibrils.
Different enzymes split the APP molecule into the benign Abeta-40, which is secreted into the CSF, and the toxic Abeta42, which forms brain plaques.
Two major forms of Abeta, Abeta40 and Abeta42, have been associated with genetic mutations causing early-onset AD, and have thus received considerable research attention.