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A gene on chromosome 21q21.3 that encodes a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form various peptides.

Molecular pathology
APP mutations are implicated in autosomal dominant Alzheimer’s disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).


Amyloid beta peptide. It is the toxic peptide that causes damage to neurons in patients having Alzheimer disease.
References in periodicals archive ?
Caffeoylquinic acid, a substance found for example in coffee beans and Centella asiatica, has been shown to be protective against cytotoxicity caused by Abeta and additionally to reduce beta-sheet formation of Abeta peptides in neuroblastoma cell lines (Gray et al.
The first model, which expresses high levels of the Abeta peptides, seems to realistically model the human form of AD, and could be used for elucidating the mechanism of Abeta deposition.
Although bapineuzumab didn't show any clinical benefits, it did apparently engage its main target: brain plaques composed of aggregated Abeta.
The oligomeric insulin was dispensed first using a standard pipette, followed by the small and pure insulin, and then the larger polydisperse Abeta samples.
During this symposium, Probiodrug and Alzheimer's disease experts from Brigham and Women's Hospital, University of Leipzig, University of Amsterdam and the RIKEN Brain Science Institute will present evidence elucidating the role of pyroglutamated (pGlu) Abeta in the pathology of Alzheimer's disease.
Louis, found that the circadian pattern of Abeta secretion is altered in Alzheimer's disease.
The options include 2DB, MRG, ABetA, and an Arkle system from Ireland that I want to find out more about, plus for us, an obvious solution of the Bookmakers Technology Consortium, which deals excellently with 2DB and GtechG2 [popularly known by its old Finsoft name] systems.
RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.
The role of longer Abeta species, in contrast, which also exist in the brains of Alzheimer's patients, has not yet been fully investigated.
El modo de aplicacion de la TENS en las seis participantes fue de tipo convencional, modalidad usada como una buena opcion de tratamiento, al ser mas tolerada que la TENS acupuntura o nivel motor; el objetivo de la TENS convencional es la estimulacion selectiva de la fibras aferentes Abeta para bloquear las aferencias dolorosas a la medula segun la teoria de la puerta de Melzack y Wall (10, 13).
Services are available on abeta pilot basis and the four metros are ready to go but we want to achieve 100% readiness (before launching officially )," Mr Mittal said.