Abelcet


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Related to Abelcet: Ambisome

Abelcet®

A liposomal preparation of amphotericin B, which somewhat reduces amphotericin’s side effects, which include high fever, shaking chills, hypotension, anorexia, nausea, vomiting, headache, dyspnoea and tachypnoea, drowsiness, generalised weakness, nephrotoxicity, hypokalaemia, hypomagnesaemia, hepatotoxicity, leukopaenia, thrombopaenia, cardiac arrhythmias—including ventricular fibrillation—and heart failure

Abelcet

A brand name for the antifungal drug AMPHOTERICIN B in a liquid complex. It is given by injection.
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The company has developed or acquired a number of marketed products, including PEG-INTRON, marketed by Schering-Plough, and ABELCET, ONCASPAR, ADAGEN, and DEPOCYT, which are all marketed in North America by Enzon's hospital and oncology sales forces.
Abelcet is indicated for the treatment of invasive fungal infections where conventional amphotericin B is ineffective or not tolerated.
New junior doctor Dr Kiran Tawana prescribed Amphotericin but referred to a problematic internet version of the medicines manual e-BNF, which took her to a page for Abelcet and the 5mg dose, which she assumed was the same for all types of the drug.
She prescribed the five milligram dosage from an Internet page about Abelcet but used the generic name of Amphotericln, which ward staff routinely took to mean the "conventional" form.
The doctor looked at one form of Abelcet and assumed It was the same dosage for the conventional Amphotericln," said Dr Rayner.
A mix-up occurred as original Amphotericin, branded as Fungizone and referred to as "conventional", has a dose of around one milligram per kg, but modern forms, branded as Ambizone and Abelcet, have dosages of three and five milligrams per kg.
THE troubled pharmaceutical giant Elan has staged an extraordinary general meeting in Dublin yesterday to secure approval for the sale of one of its major assets, the Abelcet drug.
It said that that this figure, which is considered key to the company's recovery plan, should exceed $1 billion when deals for its Abelcet and Actiq drugs are closed.
American company Cephalon acquired treatment Actiq just a` day after Elan announced on Wednesday that it had sold the rights of its antifungal treatment Abelcet for US$370 to another US drugs company.
The Abelcet average selling price has declined by 3% from the second quarter of 2008.