abacavir


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abacavir

 [ah-bak´ah-vir]
a non-nucleoside reverse transcriptase inhibitor used as an antiretroviral in treatment of human immunodeficiency virus infection; administered orally as the sulfate salt.

abacavir

/abac·a·vir/ (ah-bak´ah-vir) a nonnucleoside reverse transcriptase inhibitor used as the sulfate salt as an antiretroviral in the treatment of human immunodeficiency virus infection.

abacavir

(ə-băk′ə-vîr′)
n.
An antiviral drug, C14H18N6O, that is a nucleoside reverse transcriptor inhibitor and is used in its sulfate form in combination with other drugs for the treatment of HIV infection.

abacavir

an antiviral that is a nucleoside reverse transcriptase inhibitor.
indication It is prescribed in combination with other antiretroviral agents for HIV-1 infection.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Hypersensitivity reactions occur in approximately 5% of patients, and can be fatal. Other life-threatening adverse effects include granulocytopenia, anemia, and lactic acidosis. Common side effects include fever, headache, malaise, insomnia, nausea, vomiting, diarrhea, anorexia, and rash.

abacavir

An HIV-nucleoside reverse-transcriptase inhibitor (NRTI/integrase inhibitor) similar to AZT.
 
Adverse effects
Life-threatening allergic reactions—fever, dyspnea, rashes, intraoral blistering, nausea, headache.

abacavir

Ziagen, zintavir, 1592 AIDS An HIV nucleoside reverse transcriptase inhibitor–NRTI/integrase inhibitor similar to AZT Adverse effects Life-threatening allergic reactions–fever, dyspnea, rashes, intraoral blistering, nausea, headache. See AIDS, Nucleoside reverse transcriptase inhibitor, Reverse transcriptase.

abacavir

A nucleoside reverse transcriptase inhibitor drug used in combination with other anti-HIV drugs to treat AIDS. A brand name is Ziagen. In combination with lamivudine and zidovodine it is marketed as Trizivir.
References in periodicals archive ?
Successful translation of pharmacogenetics into the clinic: the abacavir example.
A team from Stanford University offered the latest meta-analysis of cardiovascular risk with cART (17) and compared their findings with those of the most comprehensive abacavir analysis (13) and the early PI analysis.
Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months.
A separate analysis of DAD study data launched the controversy regarding MI risk with abacavir and didanosine.
Original description of the association of abacavir hypersensitivity with HLA alleles.
Results from the study suggested that use of abacavir within the previous six months is associated with an increased risk of myocardial infarction," the statement said.
They will be compared to 200 of each race who have taken abacavir for at least 12 weeks without hypersensitivity.
These guidelines include information about the use of abacavir ([Ziagen.
Hyderabad-based pharmaceutical firm Aurobindo Pharma (NSE: AUROPHARMA) announced on Thursday that it had been granted approval from the US Food and Drug Administration (FDA) to manufacture abacavir sulfate and lamivudine tablets, which are used in the treatment of HIV.
7) evaluated the detection of HLA-B*5701 as a marker for hypersensitivity to abacavir after confirmation of drug allergy by patch testing in Black and Caucasian patients living in the United States.
Abacavir (ABC), a nucleoside reverse transcriptase inhibitor (NRTI), has been shown to be an effective component of combination antiretroviral therapy (ART) regimens for both paediatric and adult patients.