A trial that assessed abciximab as an alternative to tPA in strokes Conclusions Patients receiving abciximab were 20% more likely to have a better outcome; neurologic recovery was 29% in the treated group vs. 16% in placebo patients
ReoPro(R) (abciximab) significantly improves the recovery of patients with ischaemic stroke when administered up to six hours after stroke onset, according to new data from AbESTT (Abciximab in Emergent Stroke Treatment Trial) presented today at the 12th European Stroke Conference in Valencia, Spain.
Taking into account the severity of stroke when assessing recovery makes clinical sense, and these AbESTT results demonstrate a significant therapeutic benefit of ReoPro in patients with ischaemic stroke.
Davalos will report that significantly more AbESTT patients treated with ReoPro within five hours of the onset of stroke achieved mRS scores of 0 or 1 (normal or near-normal function) than placebo (53.
Previous data from AbESTT confirmed the safety of ReoPro in ischaemic stroke, and demonstrated trends suggesting ReoPro may increase recovery and reduce mortality2-3.
AbESTT was a randomised, double-blind, placebo-controlled Phase IIb trial of ReoPro in 400 adult patients with acute ischaemic stroke who were able to be treated within six hours of stroke onset.
The AbESTT investigators previously reported on safety and a first set of efficacy findings.
The results of the AbESTT (Abciximab in Emergent Stroke Treatment Trial), a new study in patients with ischaemic stroke, were announced today at the American Stroke Association's 28th International Stroke Conference in Phoenix, Arizona.
The AbESTT results suggest that it may be possible to improve outcomes up to six hours after the onset of stroke," said Professor Werner Hacke of the Neurology clinic at Ruprecht Karls Universitat Heildeberg, Germany.
Lilly and Centocor are committed to further investigation of the use of ReoPro for ischaemic stroke, and the results of the AbESTT trial form a strong enough case for us to proceed with a Phase III trial of ReoPro in ischaemic stroke.
The AbESTT investigators reported on safety findings.