AZU1


Also found in: Dictionary.

AZU1

A gene on chromosome 19q13.3 that encodes an azurophil granule protein of the serine protease family (but is not itself a serine protease), which has monocyte chemotactic and antibacterial activity, and acts as an important multifunctional inflammatory mediator. The genes encoding the AZU1 protein product, neutrophil elastase 2 and proteinase 3, are in a cluster at chromosome 19pter, and all three are expressed and packaged together into azurophil granules during neutrophil differentiation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Therefore, the three more important DMRs (AZU1, LTBR, and RTEL1) attracted our attention.
It is remarkable that AZU1 and VCAM1 (Figure 4) hypomethylated in their genes presumably combine their partners (e.g., chemokines and adhesion receptors) to trigger vasculitis that can be observed in most of autoimmune conditions including RA and SLE [30, 59, 60].