AZT


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zidovudine

 [zi-do´vu-dēn]
a nucleoside analogue to thymidine, used as an antiretroviral agent in treatment of patients with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS); administered orally or intravenously. It was the first agent approved for such use.

AZT

Abbreviation for azidothymidine. See: zidovudine.

AZT

(ā′zē-tē′)
n.
An antiviral drug, C10H13N5O4, that is a nucleoside reverse transcriptase inhibitor and is used in combination with other drugs for the treatment of HIV infection. Also called zidovudine.

AZT

A nucleoside analogue used with other anti-HIV agents to manage AIDS and HIV infection.
 
Adverse effects
Long-term AZT use is associated with muscle loss, nausea, anaemia, myelosuppression, oral ulcers, bone marrow damage and headache.

AZT

3'-azido-3'-deoxythimidine, zidovudine, Retrovir AIDS A nucleoside analogue, used with other anti-HIV agents to manage AIDS and HIV infection Adverse effects Long-term AZT use is associated with muscle loss, nausea, anemia, myelosuppression, oral ulcers, BM damage, headache. See AIDS, HAART.

AZT

Abbreviation for azidothymidine.
See: zidovudine

AZT

Abbrev. for azidothymidine or Zidovudine. A drug used in attempts to control AIDS. The drug is toxic but does seem to be able to prolong life. A short course of AZT has been shown to be capable of halving the incidence of transmission of HIV from mother to baby. AZT is now commonly used in combination with other anti-HIV drugs especially protease inhibitors.

AZT

Abbreviation for azidothymidine.
See: zidovudine.
References in periodicals archive ?
There were no preneoplstic lesions in normal rats in the control group at any level of our study, also there were not any abnormal preneoplastic lesions on hepatocyte of normal rat after treatment with AZT or Pt-AZT (Figure 1), but there were some necrosis and hemorrhage after treatments with these drugs (Figures IG and H).
In subjects with anemia, AZT was substituted by d4T and in the event of non-availability, skin reactions, or hepatic dysfunction, or possible drug interactions, NVP was replaced by EFV.
To examine the effect of AZT MDA while adjusting for malaria clusters observed on maps, we used multivariate logistic models with random effects to compare odds of prevalent malaria infection for AZT MDA treatment villages with odds for control villages.
In Vitro Release Kinetic of AZT. In vitro release study was carried out in pH 6.8 phosphate buffer by using dialysis bag method using dialysis membrane having molecular weight of 12000-14000 Da.
[1,8] Naive patients or those switching from the d4T wash-out protocol received the first-line antiretrovirals that contain AZT at the daily dose of 500 mg if their body weight <60 kg and 600 mg if >60 kg.
Just over a quarter (27%) of people started treatment that included AZT. The median baseline CD4 cell count was 134 cells/[mm.sup.3]; median baseline haemoglobin was 11.3 g/dl; 60% of participants were female; and the median age was 36 years.
AZT was once the only treatment for AIDS, and it remains an important treatment, particularly in preventing the transmission of the virus from infected mothers to their unborn children.
Public Health Service recommends the use of AZT to help reduce the chances of mother-to-child transmission of HIV.
It documents the initiation and implementation of Thailand's successful programme, describing the importance of counselling, communicating and staff training; the setting up of voluntary counselling and testing; the administration of short-course AZT; support to infant feeding; community support; and monitoring and evaluation processes.
The babies themselves are also routinely treated with daily doses of an antiretroviral drug such as zidovudine (AZT) for up to a month, sometimes in combination with a single dose of nevirapine at birth, Dr.