AZACS


Also found in: Acronyms.

AZACS

Azithromycin in Acute Coronary Syndrome. A trial which asked whether the evidence suggesting an association between Chlamydia pneumoniae infection and coronary artery disease was real, and, if so, would short-term treatment with the macrolide antibiotic azithromycin reduce recurrent ischaemic events in patients admitted for unstable angina or acute myocardial infarction.
 
Endpoint
Death, recurrent MI, recurrent ischaemia necessitating revascularisation.

Logistics
Randomised, double-blind, placebo-controlled, multicentre; 1439 patients to receive azthromycin or placebo.
 
Conclusion
No association between Chlamydia pneumoniae infection and coronary artery disease (and thus, no benefit of azithromycin treatment).
References in periodicals archive ?
1,010 Successful Roxithromycin Neumann coronary stenting; 300 mg/d for et al, (20) assessed for 4 wk restenosis AZACS, 1,439 Unstable angina Azithromycin for Cercek et al (21) or acute MI 5 days; followed up for 6 mo Study, Short-term Long-term Authors Results Results Gupta & Inflammatory Reduction of Camm (13) titers fell at cardiovascular 6 months events (OR= 0.2.
Anderson said that although AZACS and WIZARD certainly don't provide any basis for routinely prescribing antibiotic therapy to prevent coronary events, they don't bury the underlying hypothesis, either.
Ongoing subanalyses of both trials, however, are expected to reveal specific groups of patients who might benefit from such therapy And, researchers are still awaiting the results of two other pending trials--one with a longer duration of treatment than WIZARD or AZACS, the other using a different antibiotic.