KISS1R

(redirected from AXOR12)

KISS1R

A gene on chromosome 19p13.3 that encodes a Gq/G11 protein-coupled receptor that signals by stimulating phospholipase C, resulting in Ca2+ mobilisation. KISS1R is highly expressed in the pancreas, placenta and brain, and slightly expressed in the small intestine, kidney, lung, liver and heart. It plays a key role in the neuroendocrine control of the gonadotrophin axis and may inhibit metastases.
References in periodicals archive ?
AXOR12, a novel human G-protein-coupled receptor, activated by peptide KISS-1.
The kisspeptins has been identified as novel multifunctional peptides having ability to stimulate GnRH/LH/FSH secretion through the activation of GPR54, a classical G protein coupled receptor, formerly known as AXOR12 or OT7T175 (Shahab et al.