KISS1R

(redirected from AXOR12)

KISS1R

A gene on chromosome 19p13.3 that encodes a Gq/G11 protein-coupled receptor that signals by stimulating phospholipase C, resulting in Ca2+ mobilisation. KISS1R is highly expressed in the pancreas, placenta and brain, and slightly expressed in the small intestine, kidney, lung, liver and heart. It plays a key role in the neuroendocrine control of the gonadotrophin axis and may inhibit metastases.
References in periodicals archive ?
G protein-coupled receptor 54 (GPR54) gene, initially cloned from rat brain in 1999, is also referred to as kisspeptin 1 receptor (KiSS-1R) or AXOR12 gene [1].
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
AXOR12, a novel human G-protein-coupled receptor, activated by peptide KISS-1.
Kisspeptin peptides are endogenous ligands for the Gprotein coupled receptor GPR54, also known in the literature as hOT7T175 or AXOR12 [16-18].
Expression of metastin and a G-protein-coupled receptor (AXOR12) in epithelial ovarian cancer.
The kisspeptins has been identified as novel multifunctional peptides having ability to stimulate GnRH/LH/FSH secretion through the activation of GPR54, a classical G protein coupled receptor, formerly known as AXOR12 or OT7T175 (Shahab et al., 2005; Thompson et al., 2004).