AXL

(redirected from AXL receptor tyrosine kinase)

AXL

A gene on chromosome 19q13.1 that encodes a receptor tyrosine kinase with a unique extracellular region that juxtaposes IgL and FNIII repeats, transducing signals from the extracellular matrix into the cytoplasm by binding growth factors (e.g., vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6)). AXL is involved in stimulating cell proliferation and mediating cell aggregation by homophilic binding.
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The company added the AXL receptor tyrosine kinase is often highly expressed in several cancer types that can lead to poor prognosis.
Aslan et al., "Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models," Molecular Therapy--Nucleic Acids, vol.
Among these DEGs, we found an alternative splicing forms in cordon-bleu WH2 repeat protein-like 1 (COBLL1), cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2), pleckstrin homology domain containing, family member 1 (PLEKHG1), and AXL receptor tyrosine kinase (AXL) genes [2].
Analysis of amino acid sequences and phylogenetic tree of AXL receptor tyrosine kinase (AXL) gene among various species.
Feldmann et al., "The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target," Cancer Biology & Therapy, vol.
Lee, "Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer," Oncotarget, vol.
BGB324 is the only selective Axl receptor tyrosine kinase inhibitor in clinical development to target tumor epithelial-mesenchymal transition and has a potential application as a novel treatment for drug-resistant solid and hematological cancers, including non-small cell lung cancer and acute myeloid leukemia.
BerGenBio, a Norway-based biopharmaceutical company, has commenced a phase 1 trial of first-in-class AXL receptor tyrosine kinase inhibitor, BGB324, it was reported on Friday.
Nakamura, "Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons," Journal of Neuroscience Research, vol, 68, no.