AURKA

(redirected from AURORA2)

AURKA

A gene on chromosome 20q13 that encodes Aurora kinase A, which is involved in regulating many early mitotic events such as entry into mitosis. Aurora A levels rise during the G2 phase and peak early in mitosis. It is highly expressed in the testes, as well as in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
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The Aurora-A is encoded by the AURKA gene (also known as AIK, Aurora/IPL1-like kinase; ARK1, Aurora related kinase 1; AURA, AURORA2; BTAK, breast tumoramplified kinase; PPP1R47, protein phosphatase 1 regulatory subunit 47; STK15, serine/threonine-protein kinase 15; STK6, serine/threonine kinase 6), located at 20q13.2 and consisting of 11 exons (Gene ID: 6790).
Scientists found one version of the Aurora2 gene was less able to interact with other genes, making it more likely to became cancerous.
Aurora2 is found in 94 per cent of cases of the most common form of breast cancer.
Experts from the Breakthrough Toby Robins Breast Cancer Research Centre in London and the University of California, San Francisco studied the Aurora2 gene, hoping that it could lead to more targeted treatments.
Aurora2 is over-expressed in 16% of all breast cancers, rising to 94% in the most common form of breast cancer -invasive ductal adenocarcinoma.
Dr Spiros Linardopoulos, head of Breakthrough's novel drug targeting team, said, ``Although genes like Aurora2 carry a lower risk of causing breast cancer than well-known, high risk sus-ceptibility genes like BRCA1 and 2, they may be a more common cause of cancer in the population.''