AURKC

AURKC

A gene on chromosome 19q13.43 that encodes Aurora kinase C, which is involved in regulating many mitotic events. Aurora C is the serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), which is critical for the correct progression through and completion of mitosis. It has redundant cellular functions with AURKB; both phosphorylate histone H3. AURKC also phosphorylates TACC1, another protein involved in cell division.
References in periodicals archive ?
The AURKs are serine/threonine kinases that are involved mainly in checkpoint regulation in the cell cycle.[sup][34] Three mammalian AURKs have been identified: AURKA, AURKB, and AURKC. The biological effect of inhibiting AURK in mitosis and its potential clinical significance were first discussed in 2003.[sup][35] Since then, increased consideration to this group has been garnered, and several AURK inhibitors were moved into Phase I/II clinical trials evaluating the treatment of malignancies.
The Aurora-C is encoded by the AURKC gene (also known as AIE2; AIK3; ARK3; AurC; SPGF5; STK13), which localizes at chromosome 19q13.43 and consists of 7 exons (Gene ID: 6795).
The AURKC promoter contains a CCAAT-box at -36 to -23 (Eukaryotic Promoter Database, Swiss Institute of Bioinformatics).