AURKB

AURKB

A gene on chromosome 17p13.1 that encodes Aurora kinase B, which is involved in regulating many mitotic events. Aurora B is the catalytic component of the chromosomal passenger complex (CPC), which is critical for the correct progression through and completion of mitosis. It phosphorylates the CPC subunits BIRC5/survivin, CDCA8/borealin and INCENP, the last of which increases AURKB activity.
References in periodicals archive ?
sup][34] Three mammalian AURKs have been identified: AURKA, AURKB, and AURKC.
sup][36] Both AZD1152 (barasertib) and ZM447439, selective AURKB inhibitors, showed apoptosis-inducing effects in preclinical research.
85) Expressions of AURKA and AURKB and related genes were correlated, and overexpression of AURKB, determined by immunohistochemistry, was significantly correlated with poor outcome.
Several genes in the set of 11 confirmed genes are known to be up-regulated or involved in other cancers: CCNB1 (cyclin B1) (16,17), AURKB (aurora B kinase) (18), SPINT2 (serine protease inhibitor 2) (19), OAZ1 (ornithine decarboxylase antizyme 1) (20), and HPV16 E7 (the E7 protein of human papillomavirus 16) (21).