Antibiotics Area under the concentration time-curves from time zero to infinity; which corresponds to a calculation of mean concentration levels of a therapeutic agent in the body See Pharmacokinetics.
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In healthy young adults, the increase in AUC0- was 26% greater than dose proportional between 80-mg and 125-mg single doses administered in the fed state.
In patients with severe renal impairment, the AUC0- of total aprepitant (unbound and protein bound) decreased by 21% and Cmax decreased by 32%, relative to healthy subjects.
Other medicinal products: Co-administration of laropiprant 40 mg with midazolam increased the AUC0- and Cmax of 1'-hydroxymidazolam, a midazolam metabolite, by 98 % and 59 %, respectively.
Following a 40 mg dose of laropiprant administered orally as two modified-release tablets of nicotinic acid/laropiprant with food, laropiprant is rapidly absorbed with a median Tmax of 1 hour, a mean AUC0- of approximately 13 Mohr, and a mean Cmax of approximately 1.