antithrombin

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antithrombin

 [an″te-throm´bin]
any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I fibrin, referring to the capacity of fibrin to adsorb thrombin and thus neutralize it.
antithrombin III a naturally occurring inhibitor of blood coagulation; it is an α2-globulin member of the serpin group, synthesized in the liver and found in the plasma and various extravascular sites. It inactivates thrombin as well as certain coagulation factors and kallikrein. Inherited deficiency of the protein, an autosomal dominant disorder, is associated with recurrent deep vein thrombosis and pulmonary emboli. Complications from the disorder are prevented and, in conjunction with heparin, treated with a preparation of antithrombin III from pooled human plasma, administered intravenously.

an·ti·throm·bin

(an'tē-throm'bin),
Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.

antithrombin

/an·ti·throm·bin/ (-throm´bin) any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I  fibrin, referring to its capacity to adsorb thrombin and thus neutralize it.
antithrombin III  a plasma α of the serpin family that inactivates thrombin and also inhibits certain coagulation factors and kallikrein. Inherited deficiency is associated with recurrent deep vein thrombosis and pulmonary emboli; the complications are prevented and treated with a preparation of antithrombin III from pooled human plasma.

antithrombin

[-throm′bin]
a plasma serine protease inhibitor that neutralizes thrombin. Antithrombin is a major coagulation control protein.

antithrombin

A plasma protein that diminishes the activity of THROMBIN, or the amount of thrombin produced during or following coagulation of the blood.

Antithrombin

Any substance that counters the effect of thrombin, an enzyme that converts fibrinogen into fibrin, leading to blood coagulation.

antithrombin

any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

antithrombin III (AT III)
an alpha2-globulin synthesized in the liver which is a natural inhibitor of clotting.
References in periodicals archive ?
ATryn is the first transgenically produced therapeutic protein and the first recombinant antithrombin approved in the United States.
Results of the retrospective analysis showed that no confirmed VTEs were reported between initiation and 7 (O1) days after discontinuation of ATryn therapy.
Since then, GTC has worked on an undisclosed new use for ATryn.
GTC is due to receive a $1 million payment from Lundbeck for an initial inventory of ATryn.
The additional payments are linked to the recent FDA approval of ATryn.
ATryn is the first therapeutic product produced in transgenic animals to be approved anywhere in the world.
of Framingham said regulators cleared its drug ATryn, which is manufactured using milk from goats that have been scientifically altered to produce extra antithrombin,
4 million in spending on the ATryn program and a net reduction of approximately $1.
The recommendation from the Blood Products Advisory Committee, during a meeting in Maryland, sends the final decision on the drug ATryn to FDA officials.
Food and Drug Administration evaluation, to be presented to its Blood Products Advisory Board today, finds the drug ATryn to be effective and safe.
OB) announced today that it has signed a definitive agreement whereby the Company has regained US commercialization rights to ATryn from Lundbeck, Inc.