retinoic acid syndrome

(redirected from ATRA syndrome)

retinoic acid syndrome

complex of symptoms in patients taking all-trans retinoic acid for acute promyelocytic leukemia; comprises fever, dyspnea, weight gain, pulmonary infiltrates, pleural or pericardial effusions, episodic hypotension, renal dysfunction, and leukocytosis.

retinoic acid syndrome

A potentially fatal complication of all-trans retinoic acid (ATRA, tretinoin) therapy, which is seen in patients with acute promyelocytic leukemia, and characterised by fever, dyspnoea, weight gain, pulmonary infiltrates and pleural or pericardial effusions, ± leukocytosis.

Management
High-dose steroids (dexamethasone) begun at first signs of retinoic acid syndrome (e.g., unexplained fever, dyspnoea, weight gain, abnormal chest auscultatory findings or radiographic changes), irrespective of leukocyte count, continued for 3+ days until signs and symptoms have abated.
References in periodicals archive ?
The patient developed ATRA syndrome during follow-up observation, but the syndrome was controlled by administration of glucocorticoids.
In most of induction therapy protocols for APL, patients with high white blood cell counts are recommended to receive combination of chemotherapy and ATRA with a focus on ATRA syndrome, but the risk of FICH is not reflected in the treatment regimen.
This approach may increase the risk of ATRA syndrome, but many tactics including glucocorticoids, cytotoxic chemotherapy, mechanical ventilation remains.
4) A more serious side effect is the ATRA syndrome, which consists of high fever, respiratory distress, and transient pulmonary infiltrates with leucocytosis.
ATRA syndrome was suspected and therefore ATRA was stopped for 5 days and started on dexamethasone 4 mg twice daily.