ATRA


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Related to ATRA: ATTRA, ATRA syndrome

ATRA

A vitamin-A analogue used to manage acute promelocytic leukaemia, with the translocation t(15;17) or typical PML-RAR gene rearrangement, as it prompts the leukaemic cells to maturation.

Adverse effects
Headaches, dry skin, mouth and eyes, nausea, bone pain.
References in periodicals archive ?
Despite these groups' claims that sweeping tort "reform" measures continue to sail through state legislatures, by all appearances, organizations like ATRA have become increasingly ineffective at pushing through their agenda.
Despite an excellent initial response to ATRA, APL cells develop resistance and relapse occurs in APL patients treated with ATRA alone.
As the law now stands, suits can be brought by "private attorneys general" claiming to represent the public even when no consumers or competitors have been harmed and no laws have been broken, ATRA says.
By 1992, ATRA had hired a public relations firm to help it reach its "tort reform" goals by creating local "grassroots" front groups.
The patient received ATRA therapy and achieved hematologic remission in 12 weeks (point 5).
I Employees and Die self-employed will be affected by the expiration of the 2% payroll tax holiday--a provision that ATRA did not extend.
Using mainly available public data sources, ATRA has selected 15 criteria contributing to a general safety profile.
Using mainly available public data sources , ATRA has selected 15 criteria contributing to a general safety profile.
atRA is a pleiotropic, paracrine or autocrine signaling molecule produced from vitamin A through oxidative reactions carried out by the cytosolic retinaldehyde dehydrogenases RALDHl, RALDH2, and RALDH3 (Duester 2008).
Together, the ATRA drug and RAR-B gene act as a brake on cancer cell growth.
ATRA has selected etisalat Afghanistan, the fastest growing telecommunications network in the country, to implement the Rural Telecom Development project in 17 rural districts in nine provinces by building and operating 23 BTS sites.
Unfortunately, retinoid therapy produces some severe side-effects when ATRA levels rise too high, leading to conditions such as retinoid dermatitis, dry scaly skin and birth defects during pregnancy [6,7].