ATP6V1C1

ATP6V1C1

A gene on chromosome 8q22.3 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.
References in periodicals archive ?
It encodes a vacuolar component of ATPase (V-ATPase) (Curtis and Kane 2002), an enzyme multisubunit that mediates the acidification of eukaryotic intracellular organelles (27) ATP6V1C1 and ATP6V1C2 a and b, two alternative transcript variants encoding different isoforms, have been identified in this gene.
Our research group has found that ATP6V1C1 levels were significantly higher in patients with OSCC than in healthy controls, with expression increasing with higher tumor stage.
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.