ATP6V0E1

ATP6V0E1

A gene on chromosome 5q35.1 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.
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Pathway P value FDR Synaptic vesicle 3.36E - 08 3.58E - 05 cycle Rheumatoid 3.43E - 07 3.66E - 04 arthritis Collecting duct 2.29E - 08 2.44E - 05 acid secretion Pathway Nodes Synaptic vesicle ATP6V0C, ATP6V1A, ATP6V0E1, ATP6V1E1, ATP6V1H, cycle ATP6V0A1, ATP6V1D Rheumatoid ATP6V0C, ATP6V1A, ATP6V0E1, ATP6V1E1, ATP6V1H, arthritis ATP6V0A1, ATP6V1D Collecting duct ATP6V0C, ATP6V1A, ATP6V0E1, ATP6V1E1, ATP6V0A1, acid secretion ATP6V1D Table 4: Cox multivariate analyses of biomarkers associated with OS in the generation and validation datasets.