ATP5B

ATP5B

A gene on chromosome 12q13.13 that encodes a subunit of mitochondrial ATP synthase, an enzyme that catalyses ATP synthesis, utilising an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: a soluble catalytic core and F1—which consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, a single subunit of the other 3, as well as a membrane-spanning component, Fo, which comprises the proton channel.
References in periodicals archive ?
In addition, two subunits of mitochondrial ATP synthase (encoded by ATP5B and ATP5H) were also increased.
sup][37] According to our results, the increased ATP5B and ATP5H encode the beta subunit of F1 and d subunit of the F0 complex, respectively.
These genes included succinate dehydrogenase (SDHC), cytochrome c oxidase (COX5B/ COX6B), and various genes of the ATP synthase complex (ATP5G1, ATP5C1, ATP5J, ATP5B, ATP5A1, ATP50, and ATP5F1).