ATP4A | definition of ATP4A by Medical dictionary
ATP4A A gene on chromosome 19q13.1 that belongs to a family of P-type cation-transporting ATPases; it is composed of heterodimers consisting of a high molecular weight catalytic alpha subunit and a smaller, heavily glycosylated beta subunit, which catalyse the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane and are responsible for gastric acid secretion. Overactivity of H+, K+-ATPases causes gastric inflammation; these transporters are the pharmacologic target in the treatment of peptic ulcer disease, dyspepsia and gastro-oesophageal reflux disease (GERD/GORD).
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References in periodicals archive
Housekeeping genes GAPDH (b), ACTB (c), G6PD (d), ALDOA (e), TAF (f), and GPI (g) and nonliver genes ATP4A
(h), ATP4B (i), PGC (j), and MSN (k) exhibited similar expression among all study groups.
One of the human genes encoding [H.sup.+]/[K.sup.+]-ATPase (ATP12A/ ATP1AL1) is expressed in the brain, colon, and placenta, while the other gene (ATP4A
) is only expressed in gastric epithelial cells .
cerevisiae) Bt.28236.1.A1_at ATP4A
ATPase, H+/K+ exchanging, alpha polypeptide Bt.17742.1.A1_at -- -- Bt.20225.1.S1_at DTNBP1 Dystrobrevin binding protein 1 BtAffx.1.9.S1_at NPPA Natriuretic peptide precursor A Bt.19219.1.S1_at -- -- Bt.5386.1.S1_at COBRA1 Cofactor of BRCA1 Bt.25049.1.S1_at TRAM1L1 Translocation associated membrane protein 1-like 1 Bt.13929.2.S1_at DPH3 DPH3, KTI11 homolog (S.