ATP2B4 | definition of ATP2B4 by Medical dictionary
ATP2B4 A gene on chromosome 1q32.1 that encodes a magnesium-dependent P-type ion transport ATPase, which forms an aspartyl phosphate intermediate during the reaction cycle. P-type primary ion transport ATPases remove bivalent calcium ions from eukaryotic cells against very large concentration gradients, and play a key role in intracellular calcium homeostasis.
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References in periodicals archive
Novel membrane-associated proteins including cytoskeleton-associated protein 4 (CKAP4), polymeric immunoglobulin receptor (PIGR), transmembrane and coiled-coil domain protein 3 (TMCC3) and CD75; and others that are involved in BCR signaling like lymphocyte transmembrane adapter 1 (LAX1), C-type lectin domain family 17 member A (CLEC17A) and plasma membrane calcium-transporting ATPase 4 (ATP2B4
); were also reported with elevated expression in the CLL samples.
Exome sequencing identified rare variants in genes HSPG2 and ATP2B4
in a family segregating developmental dysplasia of the hip.