Association of common variants in/near six genes (ATP2B1
, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.
Several SNPs in genes involved with ion transport have been associated with blood pressure (e.g., ATP2B1, CACNA1D, CACNA2D2, CACNB2, KCNK3, SLC4A7, and SLC39A8; Table 1).
Tabara et al., "Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation," Hypertension, vol.
Ji et al., "Silencing of Atp2b1 increases blood pressure through vasoconstriction," Journal of Hypertension, vol.
ATP284 plasma membrane calcium-transporting ATPase 4 (1028 aa) ATP2B1
plasma membrane calcium-transporting ATPase 1 (1220 aa) ATP2B2 plasma membrane calcium-transporting ATPase 2 (1198 aa) A7P2B3 plasma membrane calcium-transporting ATPase 3 (1206 aa) CNBP Cellular nucleic acid-binding protein; Single stranded DNA -binding protein, with specificity to the sterol regulato..
The study showed that changes in gene called ATP2B1
were associated with both blood pressure and hypertension.
Subsequently, intracellular calcium ions are extruded to outside of epithelial cells by sodium/calcium exchanger 1 (SLC8A1) and plasma membrane calcium ATPase 1 (ATP2B1).
ATP2B1, a calcium ion extrusion-related molecule, is present in the uterine endometrium in rats and humans (Kim et al., 2006; Yang et al., 2011).