ATP1B4

ATP1B4

A gene on chromosome Xq24 that encodes an enzyme belonging to the family of Na+/K+ and H+/K+ ATPases, which, while found in all vertebrates, has lost its ancestral function as a Na,K-ATPase beta-subunit in placental mammals (in which it interacts with the nuclear transcriptional coregulator SKIP); it may be involved in regulating TGF-beta signalling during muscle development through its interaction with SNW1.
References in periodicals archive ?
sup][18] indicated that ATP1B4 and FGA were associated with endometriosis pathogenesis.
We found 5 stable peaks at 4210, 5264, 2660, 5635, and 5904 Da as potential EM biomarkers, the strongest of which were associated with ATP1B4 (4210 Da) and FGA (5904 Da); this indicates that ATP1B4 and FGA are associated with EM pathogenesis.
LC-MS/MS sequencing showed the 4210 Da peptide to correspond uniquely to ATP1B4, and the 5904 Da protein to FGA isoform 1/2 subunit.
ATP1B4 is crucial in forming functionally active X, K-ATPases.