In individual 1319, differential expression of cardiac conduction related genes inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) and ATPase [Na.sup.+]/[K.sup.+] transporting subunit beta 1 (ATP1B1) were observed following cisapride treatment, and potassium channel subfamily K member 1 (KCNK1) with isoproterenol treatment.
ATP1A1, ATPase [Na.sup.+]/[K.sup.+] transporting subunit alpha 1; ATP1B1, ATPase [Na.sup.+]/[K.sup.+] transporting subunit beta 1; CALM3, calmodulin 3; CAMK2B, Calcium/calmodulin-dependent protein kinase type II beta chain; Cmax, maximum concentration in blood plasma; CV, coefficient of variation; DMSO, dimethyl sulfoxide; hERG, human ethera-go-go-related gene; ITPR2, inositol 1,4,5-trisphosphate receptor, type 2; iPSC, induced pluripotent stem cell; IVIVE, in vitro-to-in vivo extrapolation; PLN, phospholamban; KCNK1, potassium channel subfamily K member 1; PRKACA, catalytic subunit a of protein kinase A; RED, rapid equilibrium dialysis; RFU, relative fluorescence units
The development of genetic studies has revealed that some SNPs within genes, such as ATP1B1
, CD36 , CYP2J2 , CYP4A11 [24, 25], CYP4F2 , CYP17A1 , and TPRC6 , are closely related to the progression of EH.
subunit of Na+/K+-gTPase FACL6 Fatty acid Coenzyme A ligase long-chain 6 ATP1B1
Beta subunit of Na+/K+ATPase MGLL Monoglyceride lipase ATP5C1 ATP synthase H+ transporting mitochondria) F1 complex PDHA2 Pyruvate dehydrogenase E1 alpha 2 ASPH Aspartylbeia-hydroxylase 1_965027 Containing a cache domain PECI Peroxisomal D3, D2-enoyl-CoA isomerase TXNIP Vitamin D-3 up-regulated protein-1 Unknown FLJ22662 Unknown MGC13269 Unknown AGTPBPt Unknown TRAP25 Unknown 1_1100083 Unknown Ctorf21 Unknown KIAA0125 Unknown HSPC053 Unknown DKFZp434G0920 Unknown 1_1151996 Unknown Myocardium (Myoc) metastatic neuroblasts.
Porcine chromosome SSC 4p13 contains a synteny group, with F13B, ATP1B1
, GBA, ATP1A1, IVL, and two microsatellites S0001, S0067 (Andersson et al., 1994; Marklund et al., 1999).