is the earliest discovered factor expressed in the prosensory domain associated with sensory hair cells.
Chi et al., "Survival and fate of transplanted embryonic neural stem cells by Atoh1
gene transfer in guinea pigs cochlea," Neuroreport, vol.
Peignon et al., "Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1
)," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kawamoto et al., "Auditory hair cell replacement and hearing improvement by Atoh1
gene therapy in deaf mammals," Nature Medicine, vol.
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Response of the flat cochlear epithelium to forced expression of Atoh1
. Hear Res 2008; 240: 52-56, doi: 10.1016/j.heares.
Zoghbi from Howard Hughes Medical Institute (HHMI) and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1
in susceptible brain cells.
The new research - published in the online journal PLoS Biology - focused on the ATOH1
gene in mice and humans and its fruit fly equivalent, Ato.
The researchers employed Atoh1
, the same gene that Raphael used in his study of deaf guinea pigs.
gene, first discovered in fruit flies and present in all animals (including humans), is usually active only during embryonic development.
While Sox2 has been shown to activate Atoh1
by directly binding to consensus sequences in the Atoh1
enhancer , Puligilla and Kelley found that Sox2 plays a dual role in inner ear formation .
depletion in the intestine resulted in expansion of the crypt proliferative zone and promoted enterocyte over secretory cell differentiation .