ATOH1

ATOH1

A gene on 4q22, which encodes a transcriptional regulator that activates E box-dependent transcription, resulting in differentiation of neural-cell subsets.
References in periodicals archive ?
Atoh1 is the earliest discovered factor expressed in the prosensory domain associated with sensory hair cells.
Chi et al., "Survival and fate of transplanted embryonic neural stem cells by Atoh1 gene transfer in guinea pigs cochlea," Neuroreport, vol.
Peignon et al., "Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kawamoto et al., "Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals," Nature Medicine, vol.
Chen et al., "In vivo delivery of Atoh1 gene to rat cochlea using a dendrimer-based nanocarrier," Journal of Biomedical Nanotechnology, vol.
Response of the flat cochlear epithelium to forced expression of Atoh1. Hear Res 2008; 240: 52-56, doi: 10.1016/j.heares.
Zoghbi from Howard Hughes Medical Institute (HHMI) and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells.
The new research - published in the online journal PLoS Biology - focused on the ATOH1 gene in mice and humans and its fruit fly equivalent, Ato.
The researchers employed Atoh1, the same gene that Raphael used in his study of deaf guinea pigs.
The Atoh1 gene, first discovered in fruit flies and present in all animals (including humans), is usually active only during embryonic development.
While Sox2 has been shown to activate Atoh1 by directly binding to consensus sequences in the Atoh1 enhancer [14], Puligilla and Kelley found that Sox2 plays a dual role in inner ear formation [31].
Atoh1 depletion in the intestine resulted in expansion of the crypt proliferative zone and promoted enterocyte over secretory cell differentiation [109].