ATG16L1

(redirected from ATG16L)

ATG16L1

A gene on chromosome 2q37.1 that encodes a peripheral membrane protein which plays an essential role in autophagy.

Molecular pathology
Genetic variations in ATG16L1 are associated with increased susceptibility to inflammatory bowel disease type 10, especially Crohn’s disease.
References in periodicals archive ?
Furthermore, the phagophore expands after conjugation of ATG12 to ATG5 which interacts with ATG16 forming the ATG16L complex which then conjugates phosphatidylethanolamine (PE) to the procures of microtubule-associated protein 1 light chain 3 (LC3) until generation of the LC3 II receptor.
The phagophore is elongated by the autophagy proteins ATG12-ATG5 creating the ATG16L complex, which then conjugates phosphatidylethanolamine (PE) to the procures of microtubule-associated protein 1 Light Chain 3 (LC3) to generate the LC3 II receptor.