ATF3


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ATF3

A gene on chromosome 2q32 that encodes a member of the activation transcription factor/cAMP-responsive element-binding family. The gene is induced by various signals, including those evoked by cancer cells.
References in periodicals archive ?
We had established conditional CF-specific ATF3 overexpression mice (ATF3TGfl/flCol1a2-Cre+) and control mice (ATF3TGfl/flCol1a2-Cre−) as described previously,[7] and all mice were housed in a specific pathogen-free level animal house in the Beijing Institute of Heart, Lung and Blood Vessel Disease.
ATF3 Cyclic amp-dependent This protein binds the transcription factor ATF- camp response element 3 (CRE), present in many viral and cellular promoters, repressor of inflammatory response 7.
Apart from the Honeywell ATF3 engine, the airplane even features Honeywells Inertial Reference Unit, control box and Navigation Display Unit.
The antibodies against Chop, Atf3, TATA box binding protein (Tbp), and HDAC1 were obtained from Santa Cruz Biotechnology (CA, USA).
33'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.
It looks like the spread of breast cancer is associated with turning on a stress gene called ATF3 (Activating Transcription Factor 3).
Song et al., "A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: controlled by ATF3," Cellular Signalling, vol.
Amundson et al., "ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth," Oncogene, vol.
The transcriptional regulator, ATF3, plays a key role in this process.
Recent evidence claims that this factor can induce apoptosis in prostatic cancer cells via up-regulation of activating transcription factor 3 (ATF3).1 ATF3 is a pro-apoptotic protein and a key mediator for apoptosis under stressful conditions.
Upregulation of the translation of ATF4 and other target proteins can then lead to increased transcription of stress-related genes (such as Atf3, Asns, Cebpb, and Trib3), allowing the cell to synthesize the subset of proteins needed to respond to the stress that initiated the response [10-12].
Three genes were chosen for investigation based on their previously identified stress roles: Nuclear Factor Kappa p (NF[kappa]B), Tumor Necrosis Factor a (TNF[alpha]), and Activating transcription factor 3 (Atf3).