ATF2


Also found in: Acronyms.

ATF2

A gene on chromosome 2q32 that encodes a transcription factor of the leucine zipper family of DNA binding proteins, which binds to the cAMP-responsive element (CRE) and stimulates CRE-dependent transcription.
Mentioned in ?
References in periodicals archive ?
Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.
This work also reveals that the ratio of ATF2 to MITF in the nucleus of melanoma cells can predict survival in melanoma patients - relatively high amounts of ATF2 and correspondingly low MITF levels were associated with a poor prognosis.
disrupted the ATF2 gene in the melanocytes of mice harboring mutations often seen in human melanoma.
It turns out that ATF2 blocks MITF function in the early stages of melanocyte development.