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ATACArimidex or Tamoxifen Alone or in Combination trial. A trial comparing anastrozole (Arimidex) and/or tamoxifen in managing early breast cancer (BC).
Conclusion Arimidex can be used for any stage BC, is better than tamoxifen, and may reduce the risk of BC in contralateral breast.
Cons Increased musculoskeletal disorders, e.g., joint symptoms—arthritis, arthrosis, arthralgia; fractures of spine, hip, wrist.