ARID1A

(redirected from AT-rich interactive domain-containing protein 1A)

ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Indexes FRBI dose TP ARID1A PTEN TP -0.758 ARID1A 0.944 * -0.928 * PTEN 0.934 * -0.571 0.829 FSHRm -0.993 ** 0.827 -0.976 ** -0.911 * FSHRp -0.937 * 0.501 -0.788 -0.984 ** p-FSHR 0.881 * -0.457 0.742 0.966 ** IP3 -0.438 -0.105 -0.172 -0.415 Indexes FSHRm FSHRp p-FSHR TP ARID1A PTEN FSHRm FSHRp 0.898 * p-FSHR -0.848 -0.968 ** IP3 0.341 0.553 -0.395 FRBI: FSH receptor binding inhibitor; TP: total proteins in ovarian tissue; ARID1A: AT-rich interactive domain-containing protein 1A; PTEN: phosphatase and tensin homolog; FSHRm: follicle-stimulating hormone cognate receptor mRNAs; FSHRp: FSHR proteins; p-FSHR: ovarian phosphorylated-FSHR; IP3: inositol trisphosphate.