ASSENT 3 PLUS

Assessment of the Safety of a New Thrombolytic-3 Plus. A clinical trial comparing enoxaparin and unfractionated heparin in prehospital management of acute myocardial infarction; ASSENT 3 PLUS failed to meet its primary outcome.

References in periodicals archive ?

The 1,639-patient, international, multicenter, randomized, open-label ASSENT 3 PLUS clinical trial was a satellite study of the larger hospital-based ASSENT 3 trial.

Lars Wallentin, Uppsala University, Uppsala, Sweden, and principal investigator of the ASSENT 3 PLUS study.

ASSENT 3 PLUS was a descriptive study with two main, pre-specified composite endpoints: a composite efficacy endpoint to evaluate efficacy outcomes, and an "efficacy plus safety" composite endpoint to evaluate efficacy improvements when safety adverse events were added to the analysis.

PRE-HOSPITAL THROMBOLYTIC HEART ATTACK TREATMENT FEASIBLE

An additional 1,000 patients will be randomized into a satellite study, ASSENT 3 Plus, investigating pre-hospital administration of either TNKase with enoxaparin sodium or TNKase with heparin sodium.