MAP3K6

(redirected from ASK2)

MAP3K6

A gene on chromosome 1p36.11 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K6 activates the JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic reticulum stress, but does not activate ERK or P38 signalling pathways.
 
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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References in periodicals archive ?
3), dvi strobavimo impulso kintamo velinimo grandines VG1 bei VG2 ir du analoginiai skaitmeniniai keitikliai ASK2 ir ASK3.
cia [A.sub.1]--pirmojo atraminio harmoninio virpesio amplitude, kuri nustatoma iU [y.sub.1] imciu aibes taikant histogramos matavimo metoda, o keitikliu ASK2 ir ASK3 atitinkamai matuojamos [y.sub.1] ir [y.sub.2] imciu vertes.
Apskaiciuotos padeties neapibrePtis Uiuo atveju daugiausia priklausys nuo ASK2 ir ASK3 (6 pav.) skilciu skaiciaus.
However, activation of ASK1 by high levels of OS (via oxidization of two cysteine residues in the redox center of thioredoxin) induces ASK1 dissociation and allows its complete oligomerization with tumor necrosis factor-a receptor associated factor (TRAF) and ASK2, thereby promoting cell death.
Two main operator consoles (ASK1, ASK2) contain control processors, keyboards, control and display.
Same work using feature based approach in past for classification of (ASK2 ASK4 PSK2 PSK4 FSK2 FSK4) with a success rate of 90% at SNR 10 dB [7].
It is used to discriminate FSK2 FSK4 from ASK2 ASK4 PSK2 and PSK4.
(26,27) Mammals also express ASK2, which is another MAP3K highly homologous to ASK1.
ASK2 was originally identified as an ASK1interacting protein.
Nevertheless, accumulating evidence suggests that the diverse functions of ASK1 and ASK2 in apoptosis, inflammation, proliferation, and migration are involved in tumorigenesis.
MAPKK kinases that regulate activation of p38 MAPK include kinases (Mlk1, Mlk2, Mlk3, Dlk, and Lzk), Mekk kinases (Mekk1, Mekk2, Mekk3, and Mekk4), Tak1, Ask1, Ask2, and Tpl- (2.20-26) Activation of the MAPKK kinases or MAPKKs occurs downstream from small G proteins whose function is regulated by the guanine exchange factor proteins.
In this paper we have considered the following digital signals: ASK2, ASK4, ASK8, PSK2, PSK4, PSK8, QAM16, QAM32, QAM64, Star-QAM8, and V32.