MAP3K6

(redirected from ASK2)

MAP3K6

A gene on chromosome 1p36.11 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K6 activates the JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic reticulum stress, but does not activate ERK or P38 signalling pathways.
 
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
3), dvi strobavimo impulso kintamo velinimo grandines VG1 bei VG2 ir du analoginiai skaitmeniniai keitikliai ASK2 ir ASK3.
1] imciu aibes taikant histogramos matavimo metoda, o keitikliu ASK2 ir ASK3 atitinkamai matuojamos [y.
Apskaiciuotos padeties neapibrePtis Uiuo atveju daugiausia priklausys nuo ASK2 ir ASK3 (6 pav.
It is used to discriminate FSK2 FSK4 from ASK2 ASK4 PSK2 and PSK4.
26,27) Mammals also express ASK2, which is another MAP3K highly homologous to ASK1.
ASK2 was originally identified as an ASK1interacting protein.
Nevertheless, accumulating evidence suggests that the diverse functions of ASK1 and ASK2 in apoptosis, inflammation, proliferation, and migration are involved in tumorigenesis.
103) The observation that ASK2-deficient keratinocytes show resistance to DMBA-induced apoptosis suggests that ASK2 suppresses tumorigenesis by eliminating damaged cells during the tumour initiation phase.
The evidence described in this review strongly suggests that ASK1 and, in some cases, ASK2 play pivotal roles in the pathogenesis and pathology of a wide range of diseases in which ROS and/or ER stress may be common pathogenic factors.
In this paper we have considered the following digital signals: ASK2, ASK4, ASK8, PSK2, PSK4, PSK8, QAM16, QAM32, QAM64, Star-QAM8, and V32.