Second, during ER stress, TRAF2 dissociates from the complex of TRAF2/procaspase-12 located in the ER membrane; the process activates caspase-12 and recruits the IRE1/JNK/TRAF2 complex that modulates ASK1
that in turn phosphorylates JNK and induces cell apoptosis .
They did not influence the expression of ASK1
and JNK but reduced the phosphorylation ofASK1 and JNK.
La interaccion de la caspasa-11 con la proteina Aip1 (proteina que interactua con la proteina ASK1
), es capaz de promover la despolimerizacion de actina con la ayuda de cofilina, como evento molecular de activacion del inflamasoma, el cual desencadena un incremento en la fusion de lisosomas a fagosomas y para liberar el ARN mensajero bacteriano al citosol para activar el inflamasoma NLRP3; sin embargo la funcion precisa de caspasa-11 durante el ensamblaje del inflamasoma sigue sin ser definida.
In addition, 24% of melanomas were found to exhibit MAP3K5 (MAP kinase kinase kinase 5; synonyms: ASK1
, MEKK5) and MAP3K9 (MAP kinase kinase kinase 9; synonyms: MlK1, MEKK9) mutations.
Starting with Juicy M (not the Godfather of UK House that's JAZZY M) who plays Hush nightclub tonight as part of her Irish tour in association with ASK1
A range of MAP3Ks have been implicated in the activation of the p38 MAPK pathway, including MLKs (mixed-lineage kinases), TAK1 (transforming growth factor [beta] activated kinase 1), ASK1
(apoptosis signal-regulating kinase 1), TAO (thousand-and-one amino acid), DLK1 (dual-leucine-zipper-bearing kinase 1) MEKKs, and ZAK1 (leucine zipper and sterile-[alpha] motif kinase 1) (Figure 1).
This p38 MAPK is known to be activated directly through hyperglycemia mediated apoptosis signal regulating kinase1 (ASK1
) or indirectly through oxidative stress.
Meanwhile, MAPK signaling pathway molecules including MEKK1, ASK1
(MAP3K5), MLK2 (MAP3K10), MLK3, NIK, MEK1 (MAP2K1), MEK2 (MAP2K2), MEK4 (MAP2K4), MEK7 (MAP2K7), ERK1 (MAPK3), JNK1 (MAPK8) and JNK2 (MAPK9) were significantly up-regulated and revealed 2.00-4.09 fold increases in expression level (Table 1).
(6.) Emmanuel Sturchler, Daniel Feurstein, Patricia McDonald and Derek Duckett: ASK1
and Its Role in Neurodegenerative Diseases.
Apart from its direct antioxidant function, thioredoxin's interaction with apoptosis signal-regulating kinase 1 (ASK1
) can modulate gene expression of p38 MAPK and JNK .
They went on to show that the protective effect is mediated by the suppression of p38MAPK and JNK levels in the brain thereby leading to inhibition of activation of apoptosis signal-regulating kinase-1 (ASK1
In their study report, they have revealed that the expression of one of the upstream signaling components, a protein called ASK1
, predicts whole-body insulin resistance (an endocrine abnormality that is strongly tied to diabetes and cardiovascular disease), independent of other traditional risk factors.