ASGR1 | definition of ASGR1 by Medical dictionary
ASGR1 A gene on chromosome 17p13.2 that encodes a subunit of the asialoglycoprotein receptor, which plays a key role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. Once the ligand binds to the receptor, the ligand-receptor complex is internalised and transported to a sorting organelle, where receptor and ligand part ways. The receptor then returns to the cell membrane to continue the cycle.
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References in periodicals archive
In newer studies, the role of modulation of the receptor asialo-glycoprotein receptor 1 (ASGR1
) is being explored.
In another experiment, T cells with two complementary CARs against GPC3 and asialoglycoprotein receptor 1 (ASGR1
) decreased the risk of on-target, off-tumor toxicities and demonstrated potent antitumor immune responses targeting GPC3+ ASGR1+ HCCs both in vivo and in vitro .
Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1
-- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor.