ASGR1

(redirected from ASGPR1)

ASGR1

A gene on chromosome 17p13.2 that encodes a subunit of the asialoglycoprotein receptor, which plays a key role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. Once the ligand binds to the receptor, the ligand-receptor complex is internalised and transported to a sorting organelle, where receptor and ligand part ways. The receptor then returns to the cell membrane to continue the cycle.
References in periodicals archive ?
During the second stage, from 9th to 14th day, albumin (ALB), ornithine transcarbamylase (TAT) as well as mRNA levels for VII clotting factor, asialoglycoprotein receptor 1 (ASGPR1), and CYP1A2 member of cytochrome P450 superfamily production are increased while AFP levels are reduced [65-68].