ASGR1

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ASGR1

A gene on chromosome 17p13.2 that encodes a subunit of the asialoglycoprotein receptor, which plays a key role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. Once the ligand binds to the receptor, the ligand-receptor complex is internalised and transported to a sorting organelle, where receptor and ligand part ways. The receptor then returns to the cell membrane to continue the cycle.
References in periodicals archive ?
Furthermore, the flexible polysaccharide blocks containing 2-5% galactan have the ability to recognize hepatocytes due to the presence of asialoglycoprotein receptors (ASGPR) on which galactose acts as a specific adhesive ligand on the hepatocytes [15-19] (Figure 2).
Asialoglycoprotein receptor (ASGPR) scintigraphy is a direct quantitative evaluation of liver function and relies on the fact that [sup.99m]Tc-galactosyl human serum albumin ([sup.99m]Tc-GSA) binds to ASGPR expressed on the surfaces of hepatocytes (4).
Asialoglycoprotein selectively binds to ASGPR, which characteristically exists on the hepatocyte surface.
[sup.99m]Tc-GSA scintigraphy is a liver scintigraphy using the synthetic glycoprotein--[sup.99m]Tc-GSA--that specifically binds to ASGPR expressed on the membrane surfaces of hepatocytes (4).
Targeting ASGPR) DC-ASGPR induces suppressive responses.
Smyk et al., "Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found," Autoimmunity Reviews, vol.
IgA has been described to interact with various host receptors, that is, pIgR, FcaRI (CD89), transferrin receptor (CD71), asialoglycoprotein receptor (ASGPR), and Fca/[micro]R.
SMA smooth musle antibodies, AAA anti-actin antibodies, SLA soluble liver antigen, LP liver-pancreas antigen, LSP liver specific protein, ASGPR asialo-glycoprotein-receptor, LKM liver kidney microsomes, CYP cytochrome P450, AMA anitmitochondrial antibodies, PDH pyruvat dehydrogenase, p-ANCA perinuclear antineutrophile cytoplasmatic antibodies, MRC magnetic resonance cholangiography, HEV hepatitis E virus, HIV human immunodeficiency virus, TTG tissue transglutaminase, TSH thyroid stimulating hormone.
Conrad, "Asialoglycoprotein Receptor (ASGPR): APeculiar Target of Liver-Specific Autoimmunity," Autoimmunity Highlights, vol.