SLC1A5

(redirected from ASCT2)

SLC1A5

A gene on chromosome 19q13.3 that encodes a sodium-dependent amino acid transporter with broad substrate specificity and a preference for zwitterionic amino acids. It accepts as substrates neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids; it excludes methylated, anionic and cationic amino acids. SLC1A5 also acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type-D simian retroviruses.
Mentioned in ?
References in periodicals archive ?
The human glutamine transporter ASCT2 makes it possible for the amino acid glutamine to invade cells and is stimulated in many types of cancer cells that need more glutamine.
Glutamine can enter the cell through glutamine transporters like ASCT2 and SLC38A5.
Bode, "Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?" Seminars in Cancer Biology, vol.
Zhou et al., "Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation," Immunity, vol.
Lu and colleagues [80] described how cetuximab downregulated a complex in the cell cytoplasmic membrane formed by a glutamine transport protein, ASCT2, and EGFR via endocytosis in HNSCC cell lines.
Fan, "ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis," Cancer Letters, vol.
Glutamine, also involved in amino acid and nucleotide biosynthesis, is taken up into the cell through the glutamine importer ASCT2 and is deaminated in mitochondria by glutaminase to form glutamate.