This Phase III study (NCT02195479) is a randomized, open-label, multicenter study that included 706 newly diagnosed patients with multiple myeloma who are ineligible for ASCT
. Patients were randomized to receive 9 cycles of either VMP [bortezomib (a proteasome inhibitor), melphalan (an alkylating chemotherapeutic agent) and prednisone (a corticosteroid)] combined with daratumumab, or VMP alone.
A large international Phase 2 study of pidilizumab conducted on 66 patients with measurable disease after ASCT
showed good outcomes with 51% ORR (34% CR, n=12; PR 17%, n=6) (30).
Patients who achieve a response to salvage therapy receive high dose chemo with ASCT
In a retrospective study at IU , 184 consecutive patients with testicular or retroperitoneal primary GCT underwent two cycles of high-dose carboplatin and etoposide, each followed by ASCT
. Carboplatin dose was calculated using body surface area (BSA), and patients in remission after HDCT received adjuvant oral etoposide for 3 months.
Ten patients had treatment containing an IMiD (5 lenalidomide and 5 thalidomide), five had high-dose salvage chemotherapy, four ASCT
, two craniocaudal irradiation, and six intrathecal chemotherapy.
After detailed review, a total of 43 studies were further excluded for the following reasons: duplicate study data, not focused on relapsed sarcoma, or not receiving ASCT
. A total of 21 articles met our inclusion criteria.
However, there are reports of disseminated disease , retinochoroiditis , or solitary spinal cord lesion  following ASCT
. Cerebral toxoplasmosis has been described in one case each following ASCT
for non-Hodgkin's lymphoma , neuroblastoma in a pediatric patient , and after tandem ASCT
for myeloma .
, invasive fungal infection [IFI] usually occurs in pre-engraftment period however can happen after count recovery as well.
PERMISSION 9 0 D Muscutt (3) 14-1 (J Fanshawe) drawn (6) 11 ran MERIDIAN'S YANKEE KHAIRAAT (3.05 ASCT
); DARTMOUTH (3.40 ASCT
); THE TIN MAN (4.20 ASCT
); THOMAS HOBSON (5.35 ASCT
the widespread introduction of rituximab, a chimeric antiCD20 antibody, and improvement in autologous stem cell transplantation (ASCT
She received four cycles of BD (bortezomib 1.3 mg/m[sup]2 day [D] 1, 4, 7, 11 and dexamethasone 20 mg D1-4, 7, 11, 21 days/cycle) treatment, and a mass of 2.5 cm in diameter in her left lung was found by computed tomography scan right before autologous stem cell transplantation (ASCT
Echocardiography (TTE) showed ejection fraction 50-55% with RVSP 63 and a slightly positive agitated saline contrast test (ASCT
) consistent with an interatrial shunting.