These patients typically receive induction therapy and high-dose chemotherapy with melphalan followed by ASCT
CALGB 100104 was a phase III, controlled, double-blind, multi-centre study of 460 patients with newly diagnosed MM undergoing ASCT
who received continuous daily treatment with Revlimid or placebo until relapse.
However, the pitfall of this systematic review was not analyzing long term FL outcomes, and the authors conclude that the choice of the regimen should be decided individually based on the need to avoid anthracycline cardiotoxicity in older patients or in young patients where salvage therapy followed by ASCT
is planned in the future.
Following the ASCT
and high-dose chemotherapy there was an improvement in motor functions, although mild numbness of the hands and feet continued.
Bone marrow examination done 12 weeks after ASCT
showed no evidence of residual disease (Figure 3).
As instrucoes do ASCT
sao enunciadas de forma dramatizada, finalizando com uma solicitacao dirigida a crianca: "Mostra-me e conta-me o que acontece agora".
In this era of novel agents, treatment varies depending on whether the patient is eligible for ASCT
Bothell, WA, announced the US Food and Drug Administration (FDA) has granted accelerated approval ofAdcetris (brentuximab vedotin) for two indications: (1) the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplant (ASCT
) or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not ASCT
candidates, and (2) the treatment of patients with systemic anaplastic large cell lymphoma (ALCL) after failure of at least one prior multi-agent chemotherapy regimen.
Repeat bone marrow biopsy performed 5 months after ASCT
showed no evidence of residual monoclonal plasma cell population, and plasma IgD concentrations remained near 0.
Although high dose melphalan with ASCT
is an effective therapy for systemic AL amyloidosis, it is associated with high mortality.
After the third treatment cycle patients who obtain a complete or partial response will receive high dose chemotherapy followed by ASCT
The investigators concluded that patient-specific, organ dosimetry-based significant dose escalation with RIT was achieved with outpatient ASCT