ASC-US


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Related to ASC-US: colposcopy, ASC-H

ASC-US

, ASCUS
atypical squamous cells of uncertain significance It is a finding on some abnormal PAP smears in which frankly dysplastic lesions are not found, but cell nuclei demonstrate minor histopathological abnormalities.
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References in periodicals archive ?
found on their 70 confirmed ASC-US samples, that 40% of their cervical samples had a concomitant non-HPV infection (5).
Considerando os resultados dos exames citopatologicos que apresentaram laudos alterados em 2016, foi possivel observar que de 217 casos, 96 (30, 68%), tiveram seus resultados compativeis com atipias de significado indeterminado, ASC-US. No ano de 2017, os valores encontrados nao diferiram muito dos apresentados no ano de 2016, visto que, dos 339 casos de laudos alterados, 185 (35,30%), correspondem ao ASC-US.
TABLA I DISTRIBUCION DE LOS RESULTADOS DE LA DETECCION DE VPH E INMUNOREACTIVIDAD PARA [p16.sup.mK4[alfa]]/Ki-67 DE ACUERDO CON LOS HALLAZGOS CITOLOGICOS Citologia VPH Tincion dual [p16.sup.INK4[alfa]]/ Ki-67 Negativo Positivo Negativa Positiva NILM (n = 11) 2 (18,0%) 9 (81,8%) 11 (100,0%) 0 ASC-US (n = 32) 14 (44,0%) 18 (56,0%) 24 (75,0%) 8 (25,0%) LSIL (n = 62) 4 (6,5%) 58 (93,5%) 35 (56,5%) 27 (44,0%) HSIL (n = 10) 1 (10,0%) 9 (90,0%) 3 (30,0%) 7 (70,0%) Total (n = 115) 21 (18,3%) 94 (81,7%) 73 (63,5%) 42 (36,5%) NILM: negativa para lesion intraepitelial o malignidad.
* cytology ASC-US, HPV positive: refer directly for colposcopy
Based on the data available as of September 2006, both the committee that reviewed atypical squamous cells and the committee that reviewed HPV DNA testing decided that HPV genotyping does not add clinical benefit to the management of women with ASC-US. This was based on the fact that only approximately 50% of CIN 2+ lesions are associated with infection with HPV 16 or 18.
The ASCUS/LSIL Triage Study (ALTS) trial is a large, multicenteric, randomized trial specifically designed to evaluate three methods of managing women with cytologic findings of ASC-US (atypical squamous cells of undetermined significance) and LSIL (low-grade squamous intraepithelial lesion) (20): (i) immediate colposcopic examination for all women; (ii) HPV testing and referral for colposcopy if the HPV test result was positive; and (iii) repeated cytologic assessment with referral for colposcopy if the smear showed the presence of HSIL (high-grade squamous intraepithelial lesion).
Although consensus guidelines for the general population call for reflex human papillomavirus (HPV) testing for women with ASC-US and colposcopic examination of the of the cervix for those with evidence of HPV infection, LSIL, and high-grade squamous intraepithelial lesions (HSIL), these guidelines do not apply to adolescents and young women, he said.
Although consensus guidelines for the general population call for reflex human papillomavirus (HPV) testing for women with ASC-US and colposcopic examination of the cervix for those with evidence of HPV infection, LSIL, and high-grade squamous intraepithelial lesion (HSIL), these guidelines do not apply to adolescents and young women, he said.