ASAH2

ASAH2

A gene on chromosome 10q11.23 that encodes an amidohydrolase which hydrolyses ceramide into sphingosine and free fatty acid, acting as a key regulator of sphingolipid-signalling metabolites by generating sphingosine at the cell surface. It represses apoptosis by reducing C16-ceramide (preventing ceramide-induced apoptosis) and by generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate.
References in periodicals archive ?
Five human ceramidase genes have been identified, including ASAH1, ASAH2, ACER1, ACER2, and ACER3, and their protein products are classified as the acid (ASAH1), neutral (ASAH2), and alkaline ceramidase (ACER1-3) subtypes according to their pH optimum for their catalytic activity [9].
At the level of phospholipid and sphingolipid metabolism, IFN-[alpha]-treated BMM upregulated phospholipid phosphatase 2 (PLPP2) and neutral ceramidase (ASAH2) and downregulated sphingolipid kinases (SPHK2, CERK) suggesting a shift away from phosphorylated sphingolipids to sphingosine in acute IFN responses (Figure 7, Supplementary Figure S7).