ASAH1

(redirected from ASAH)
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ASAH1

A gene on chromosome 8p22 that encodes a heterodimeric enzyme that is cleaved into an active form post-translationally, and which catalyses the synthesis and degradation of ceramide into sphingosine and fatty acid.

Molecular pathology
ASAH1 mutations are linked to Farber disease, a lysosomal storage disorder.
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Other pertinent information includes patient history of recent illicit drug use, hypertension, polycystic kidney disease, previous ASAH or aneurysms, use of anticoagulants, or tobacco use, which can increase the risk of aneurysm formation (Juvela, Hillbom, Numminen, & Koskinen, 1993; Schievink, Torres, Piepgras, & Wiebers, 1992).
After ASAH is excluded, a patient's SBP parameters are relaxed, allowing the patient's SBP to return to baseline.
These studies evaluated differences in outcome and prognosis in patients with ASAHs, versus NASAHs, particularly those with the perimesencephalic pattern of hemorrhage.