ARNTL2


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ARNTL2

A gene on chromosome 12p12.2-p11.2 that encodes a basic helix-loop-helix protein which forms a heterodimer with CLOCK and binding an E-box element, activating transcription. This transactivation is inhibited by clock genes PER2 and CRY1.
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We also found that in module 1, a hub lncRNA LINC00472 functioned as a hub to compete with 12 mRNAs (GATAD2B, MED13L, TSC22D1, SETD5, HIP1, ARNTL2, HMGN3, EPAS1, RELL1, ARHGEF10, ZNF532, and CTSS) and 3 lncRNAs (HCP5, HLA-F-AS1, and BAIAP2-AS1) in a 16-ceRNA module (Figure 6A), implying its important roles in LAD.