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In addition to bmalL complete RNA transcripts of the related amtl gene were identified in all three species, and the Melibe ARNTL protein was used to root the phylogenetic analysis of BMAL1 (Fig.
We recently reported that BNP mRNA contents, but not ANP mRNA contents, are produced in a circadian manner in the ventricles of wild-type mice and that the production pattern reflects the local expression of the central clock genes Perl [period homolog 1(Drosophila)] and Bmall [officially known as Arntl (aryl hydrocarbon receptor nuclear translocator-like)] (2).
Alpman et al., "Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression," Annals of Medicine, vol.
The primary transcriptional-translational feedback loop (TTFL) is controlled by the basic helix-loop-helix transcription factors CLOCK and BMAL1 (i.e., ARNTL).