ARNT

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ARNT

A gene on chromosome 1q21 that encodes aryl hydrocarbon receptor, which is involved in inducing several enzymes that participate in xenobiotic metabolism—e.g., of dioxin and polycyclic aromatic hydrocarbons—resulting in translocation of the ligand-binding subunit to the nucleus.

Molecular pathology
A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia.

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If liver cells are treated with insulin, there will be a small increase in ARNT protein.

Gene that controls abnormal sugar production in liver identified

Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-pdioxin exposure: Ah receptor and ARNT expression, CYPIA1 induction, and Ah receptor down-regulation.

Quantification of aromatic hydrocarbon receptor (AHR) and related genes by calibrated reverse transcription-PCR in blood mononuclear cells

While previous work suggested defects in other pathways in a small percentage of people with type 2 diabetes, what was unexpected was that the islets (beta cells) from all of the people with type 2 diabetes studied demonstrated a marked down-regulation of the nuclear transcription factor ARNT," said C.

Joslin Researchers Discover New Gene for Type 2 Diabetes Using DNA Chips, Findings May Provide New Target for Treating the Disease

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