These six genes are GXYLT2, SHQ1 homolog, Saccharomyces cerevisiae (SHQ1), PDZRN3, ADP-ribosylation factor-like 15 (ARL15), oxysterol binding protein 2 (OSBP2), and mevalonate kinase (MVK).
Two significant SNPs were found in the ARL15 gene on chromosome 21, which encodes the ADP-ribosylation factor-like 15.
A GWAS revealed variants in ARL15 that influence adiponectin levels involved in fatty acid breakdown (Richards et al., 2009).
This region has ARL15 genes related to two significant SNPs.
Among the regions identified by the international research team are two, near the genes ARL15
and RREB1, that also show strong links to elevated levels of insulin and glucose in the body - two key characteristics of type 2 diabetes.