AURKB

(redirected from ARK2)

AURKB

A gene on chromosome 17p13.1 that encodes Aurora kinase B, which is involved in regulating many mitotic events. Aurora B is the catalytic component of the chromosomal passenger complex (CPC), which is critical for the correct progression through and completion of mitosis. It phosphorylates the CPC subunits BIRC5/survivin, CDCA8/borealin and INCENP, the last of which increases AURKB activity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Overexpression of histone phosphorylation proteins such as ARK1 and ARK2 and histone-modifying genes, such as histone methyltransferases G9a, EZH2, and SUV39HZ, in HCC tissues predicts tissue invasion and poor prognosis [130, 156].
The Aurora-B is encoded by the AURKB gene (also known as AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM1; STK12), mapped to chromosome 17p13.1, and consisting of 9 exons (Gene ID: 9212).